Polymorphism is the ability of a solid material to exist in more than one form or crystal structure. The complete morphology of a material is described by polymorphism and other variables such as crystal habit, amorphous fraction or crystallographic defects. Polymorphism was done to increase the solubility and stability of drug. A number of methods have been employed for characterizing polymorphs in pharmaceutical solids. Polarizing optical microscopy and thermo microscopy have proven to be useful tools. Experiment was carried out for making different novel polymorphic forms of imatinib and also to check there solubility in different solvent. The six different polymorphic forms are screened for microscopic evaluation by IR spectroscopic. The FTIR studies will show that the standard imatinib will gives peaks at 1560, 981.2, 912.5, 887.8, 664.2, 843.8 and 807.8 cm-1. Apart from standard crystal parameters the IR peaks for polymorphic form P is 1598.7, 784.245, 588.182 and 702.926 cm-1. For polymorphic form Q 2200.38, 1598.7, 1455.95, 1226.96 and 700.034 cm-1. The IR peaks for polymorphic form R will show that 1455.99, 1097, 922.771 and 784.245 cm-1. The IR peak polymorphic from S 1449.24, 1013.41, 1000, 335.99, 700.09 and 529.039 cm-1. The IR peak for polymorphic form T 1082.99, 1000 and 825.384 cm-1 and IR peak for form U 1598.7, 784.245, 702.926 and 588.182 cm-1. In the present research our investigations state that formations of new six polymorphic forms are different than original forms of imatinib.
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